a tool for identifying drug-targetable redox-active disulphides

Ig heavy chain V region 5-76

Intramolecular

Cysteine 41 and cysteine 115

A redox-regulated disulphide may form within Ig heavy chain V region 5-76 between cysteines 41 and 115 (322 and 396 respectively in this structure).

Details

Redox score ?

77

PDB code

Structure name

crystal structure of dsfv mr1 in complex with the peptide antigen of the mutant epidermal growth factor receptor, egfrviii, at liquid nitrogen temperature

Structure deposition date

2001-03-14

Thiol separation (Å)

2

Half-sphere exposure sum ?

86

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

41

Residue number B

115

Peptide name

Ig heavy chain V region 5-76

Ligandability

Cysteine 41 of Ig heavy chain V region 5-76

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 115 of Ig heavy chain V region 5-76

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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